gastroplus tm software package  (Simulations Plus Inc)

Journal: Pharmaceutics

Article Title: The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

doi: 10.3390/pharmaceutics14071360

Figure Lengend Snippet: The selected input parameters for minoxidil absorption simulation.

Article Snippet: In-silico simulations were performed with the GastroPlus TM software package (v. 9.7.0009, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Molecular Weight, Solubility, Permeability, Diffusion-based Assay, Concentration Assay, Clinical Proteomics

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: The selected input parameters for furosemide absorption GastroPlus ® simulation.

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Molecular Weight, Solubility, Permeability, Diffusion-based Assay, Concentration Assay, Clinical Proteomics

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: GastroPlus ® simulated (line) versus mean observed (markers) plasma concentration profiles following p.o. administration of furosemide. Mean observed values represent 40 mg immediate-release (IR) tablet profile I and 40 mg IR tablet profile II .

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Clinical Proteomics, Concentration Assay

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: Comparison between GastroPlus ® simulated and in-vivo observed furosemide pharmacokinetic parameters following p.o. drug administration.

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Comparison

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: GastroPlus ® simulated dissolution and absorption profiles following p.o. administration of 40 mg furosemide dose (dissolution profile was simulated using the software default Johnson equation).

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Dissolution, Software

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: GastroPlus ® simulated regional absorption of furosemide following p.o. administration of 40 mg drug dose (the simulated values refer to the fraction of drug dose that entered into the enterocytes).

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques:

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: GastroPlus ® simulated furosemide dissolution profiles ( a ); and ( b ) the corresponding simulated plasma profiles; ( c ) absorption profiles; and ( d ) regional absorption distribution.

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Dissolution, Clinical Proteomics

Journal: Pharmaceutics

Article Title: BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide

doi: 10.3390/pharmaceutics12121175

Figure Lengend Snippet: GastroPlus ® predicted pharmacokinetic parameters for different furosemide virtual dissolution profiles from 40 mg p.o. dosage forms.

Article Snippet: Computer simulations of furosemide absorption and concomitant plasma concentrations following oral administration in humans were conducted using GastroPlus TM software package (v. 9.7.0009, 2019, Simulations Plus Inc., Lancaster, CA, USA).

Techniques: Dissolution